Cambridge-Africa

Dr Kwaku Kyeremeh

Dr Kwaku Kyeremeh (University of Ghana)

Research title: Isolate and characterize novel compounds from Ghanaian microbes and use cost effective assays to evaluate their bioactivity.

Research project: Currently, scientists have developed tools and technology to unlock the potential of cultivated and previously uncultivated microbes. This has prompted a sudden return to drug discovery from microbes by pharmaceutical companies and many academicians. The rejuvenated philosophy iterates the fact that new un- or underexplored extreme environments harbour novel microorganisms with the novel genetic and biosynthetic capability to produce our future drug prototypes.

Ghana has several wetlands in both the Western and Volta regions. These wetlands like their counterparts elsewhere have been found to be a great assembly point of novel marine-derived Actinomycetes. Using different media culture and fermentation techniques, bioinformatics analysis, genetic manipulation, spectrometry and spectroscopic techniques we intend to probe further the ability of microbes from Ghanaian wetlands to biosynthesis our future drugs.

Isolate and characterize novel compounds from Ghanaian microbes and use cost effective assays to evaluate their bioactivity. The project seeks to emphasize the importance of Ghana’s wetlands even beyond the ecological and socio-economic significance and offers an entirely new scientific reason why this resource should be properly managed and protected.

This project aims to build capacity and transfer sustainable scientific technology from the UK to the Ghana based collaborators. Provide baseline information and create opportunity for the development of intellectual property.

Collaborator: Professor Peter Leadlay, Department of Biochemistry, University of Cambridge